Article

Microglial MHC-I induction with aging and Alzheimer’s is conserved in mouse models and humans

2023-03-10

Abstract excerpt

Major Histocompatibility Complex I (MHC-I) CNS cellular localization and function is still being determined after previously being thought to be absent from the brain. MHC-I expression has been reported to increase with brain aging in mouse, rat, and human whole tissue analyses but the cellular localization was undetermined. Neuronal MHC-I is proposed to regulate developmental synapse elimination and tau pathology...

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Literature Corpus work: 69eb994f-e46a-5fd2-b277-752b6c6ac29a
DOI: 10.1101/2023.03.07.531435

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