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Article

The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.

Science advances - 23 Aug 2024

Hardikar Swanand, Ren Ren, Ying Zhengzhou, Zhou Jujun, Horton John R, Bramble Matthew D, Liu Bin, Lu Yue, Liu Bigang, Coletta Luis Della, Shen Jianjun, Dan Jiameng, Zhang Xing, Cheng Xiaodong, Chen Taiping

Abstract excerpt

CDCA7, encoding a protein with a carboxyl-terminal cysteine-rich domain (CRD), is mutated in immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a disease related to hypomethylation of juxtacentromeric satellite DNA. How CDCA7 directs DNA methylation to juxtacentromeric regions is unknown. Here, we show that the CDCA7 CRD adopts a unique zinc-binding structure that recognizes a CpG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39178265
DOI: 10.1126/sciadv.adr0036
PMCID: PMC11343032

Genes

CDCA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.PMID 39178265Read ↗

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