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Article

Heterochromatin protein 1 forms distinct complexes to direct histone deacetylation and DNA methylation.

Nature structural & molecular biology - 15 Apr 2012

Honda Shinji, Lewis Zachary A, Shimada Kenji, Fischle Wolfgang, Sack Ragna, Selker Eric U

Abstract excerpt

DNA methylation, methylation of histone H3 at Lys9 (H3K9me3) and hypoacetylated histones are common molecular features of heterochromatin. Important details of their functions and inter-relationships remain unclear, however. In Neurospora crassa, H3K9me3 directs DNA methylation through a complex containing heterochromatin protein 1 (HP1) and the DNA methyltransferase DIM-2. We identified a distinct HP1 complex,...

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Source

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Identifiers

PMID: 22504884
DOI: 10.1038/nsmb.2274
PMCID: PMC4957970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterochromatin protein 1 forms distinct complexes to direct histone deacetylation and DNA methylation.PMID 22504884Read ↗

The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa.Semantic proximity Read ↗

CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1Semantic proximity Read ↗

Normal Patterns of Histone H3K27 Methylation Require the Histone Variant H2A.Z in Neurospora crassa.Semantic proximity Read ↗

H2B- and H3-specific histone deacetylases are required for DNA methylation in Neurospora crassa.Semantic proximity Read ↗

KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.Semantic proximity Read ↗

Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa.Semantic proximity Read ↗

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa.Semantic proximity Read ↗

Identification of DIM-7, a protein required to target the DIM-5 H3 methyltransferase to chromatin.Semantic proximity Read ↗

The histone variant H2A.Z is required to establish normal patterns of H3K27 methylation in <i>Neurospora crassa</i>Semantic proximity Read ↗

Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation.Semantic proximity Read ↗

Heterochromatin protein 2 interacts with Nap-1 and NURF: a link between heterochromatin-induced gene silencing and the chromatin remodeling machinery in Drosophila.Semantic proximity Read ↗

Protein phosphatase PP1 is required for normal DNA methylation in Neurospora.Semantic proximity Read ↗

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