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Fully T2T pedigree assemblies reveal genetic stability and epigenetic plasticity of human centromeres across inheritance and cell-fate transitions

2026-02-17

Abstract excerpt

Centromeres are essential chromosome components yet remain poorly understood due to their highly repetitive sequence architecture. Using fully-phased telomere-to-telomere diploid assemblies from a three-generation pedigree integrated with long-read epigenomes from matched peripheral blood mononuclear cells, induced pluripotent stem cells, and neural progenitor cells, we generate allele-resolved single basepair res...

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Literature Corpus work
22be0921-e68b-54f8-9d59-9810680cc7e5
DOI
10.64898/2026.02.14.705860
Open publication

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Fully T2T pedigree assemblies reveal genetic stability and epigenetic plasticity of human centromeres across inheritance and cell-fate transitionsDOI 10.64898/2026.02.14.705860
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