Article

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

2023-02-02

Abstract excerpt

<h4>Summary</h4> 5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. The mammalian SNF2 family ATPase HELLS and its plant ortholog DDM1 are critical for maintaining 5mC. Mutations in HELLS, its activator CDCA7, and the de novo DNA methyltransferase DNMT3B, cause immunodeficiency-centromeric instability-facial anomalies (ICF)...

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Literature Corpus work: 624d4d39-33fe-5b62-b340-0fbcb5b3a54c
DOI: 10.1101/2023.01.30.526367

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