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Article

The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS.

Nucleic acids research - 23 Sept 2024

Shinkai Akeo, Hashimoto Hideharu, Shimura Chikako, Fujimoto Hiroaki, Fukuda Kei, Horikoshi Naoki, Okano Masaki, Niwa Hitoshi, Debler Erik W, Kurumizaka Hitoshi, Shinkai Yoichi

Abstract excerpt

The chromatin-remodeling enzyme helicase lymphoid-specific (HELLS) interacts with cell division cycle-associated 7 (CDCA7) on nucleosomes and is involved in the regulation of DNA methylation in higher organisms. Mutations in these genes cause immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, which also results in DNA hypomethylation of satellite repeat regions. We investigated the...

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Identifiers

PMID: 39142653
DOI: 10.1093/nar/gkae677
PMCID: PMC11417364

Genes

CDCA7
HELLS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS.PMID 39142653Read ↗

CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLSSemantic proximity Read ↗

The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.Semantic proximity Read ↗

CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeatsSemantic proximity Read ↗

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.Semantic proximity Read ↗

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferasesSemantic proximity Read ↗

Chromatin remodeling in replication‐uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studiesSemantic proximity Read ↗

DNA methylation in disease: Immunodeficiency, Centromeric instability, Facial anomalies syndrome.Semantic proximity Read ↗

CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via histone H1Semantic proximity Read ↗

Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.Semantic proximity Read ↗

The Chd family of chromatin remodelers.Semantic proximity Read ↗

Investigation into the role of LSH ATPase in chromatin remodellingSemantic proximity Read ↗

Transcriptional Activation of Human CDCA8 Gene Regulated by Transcription Factor NF-Y in Embryonic Stem Cells and Cancer CellsSemantic proximity Read ↗

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