Article

CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

2023-12-19

Abstract excerpt

Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome, characterized by hypomethylation at heterochromatin. The unique zinc-finger domain, zf-4CXXC_R1, of CDCA7 is widely conserved across eukaryotes but is absent from species that lack HELLS and DNA methyltransferases, implying its specialized relation with methylated DNA. H...

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Literature Corpus work: 4c03c283-91ea-5354-9aa7-248e67df9dab
DOI: 10.1101/2023.12.19.572350

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