Article
The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing.
Molecular cell - 19 Mar 2015
Lang Zhaobo, Lei Mingguang, Wang Xingang, Tang Kai, Miki Daisuke, Zhang Huiming, Mangrauthia Satendra K, Liu Wenshan, Nie Wenfeng, Ma Guojie, Yan Jun, Duan Cheng-Guo, Hsu Chuan-Chih, Wang Chunlei, Tao W Andy, Gong Zhizhong, Zhu Jian-Kang
Abstract excerpt
DNA methylation is a conserved epigenetic mark that plays important roles in plant and vertebrate development, genome stability, and gene regulation. Canonical Methyl-CpG-binding domain (MBD) proteins are important interpreters of DNA methylation that recognize methylated CG sites and recruit chromatin remodelers, histone deacetylases, and histone methyltransferases to repress transcription. Here, we show that...
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