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Haplotype-resolved centromeric chromatin organization from a complete diploid human genome

2026-03-31

Abstract excerpt

<h4>Summary</h4> Centromeres ensure proper chromosome segregation during cell division, yet the organization and regulation of centromeric chromatin within satellite DNA arrays remain incompletely understood. Here, we leverage the complete diploid human genome benchmark (T2T-HG002) to provide a detailed study of centromeric sequence and chromatin architecture on individual haplotypes. Using adaptive-sampling-enri...

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Literature Corpus work
07752fd2-6db5-5269-838e-d9ad1cbe5d00
DOI
10.64898/2026.03.27.714900
Open publication

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Haplotype-resolved centromeric chromatin organization from a complete diploid human genomeDOI 10.64898/2026.03.27.714900
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