Article

Dissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement

2026-06-06

Abstract excerpt

Cytoplasmic poly(A)-binding proteins (PABPCs) are essential and highly abundant regulators of mRNA stability and translation, but their cellular functions have been difficult to dissect due to slow turnover and the lethality observed upon loss of both major paralogs, PABPC1 and PABPC4. To enable structure–function analysis of PABPC in human cells, we developed a protein-replacement platform that couples rapid auxi...

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Literature Corpus work: b3b1561d-7a63-52ac-a8da-e6885e82c13e
DOI: 10.64898/2026.06.05.728833

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