Article

PABPC1 Modulates Immunoglobulin pre-mRNA Alternative Polyadenylation

2026-04-24

Abstract excerpt

Alternative polyadenylation is a mechanism by which cells tune gene expression, and dysregulation can lead to development of disease. PABPC1 has been implicated in poly(A) site selection, but its function in gene regulation remains contradictory and poorly defined. Here, we investigate its role in B cell development, where APA controls immunoglobulin secretion. To define this role, we mapped PABPC1-RNA interaction...

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Literature Corpus work: 3f61cec0-989a-503a-8a4f-48dc1ad042fc
DOI: 10.64898/2026.04.23.720383

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