Article

Distinct roles of IDR and CCD domains control PABPN1 aggregation and enable therapeutic rescue

2026-06-16

Abstract excerpt

PABPN1 is a multifunctional protein whose expression is tightly regulated to maintain cellular homeostasis. PABPN1 dysregulation contributes to both common acquired diseases, such as bladder cancer, and rare inherited disorders, including oculopharyngeal muscular dystrophy (OPMD). In OPMD, PABPN1 forms insoluble aggregates that reduce its functional levels, leading to genome-wide shifts in alternative polyadenylat...

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Literature Corpus work: e4327d47-b814-5405-98e5-f66e031d7afb
DOI: 10.64898/2026.06.12.731084

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