Article

Mammalian Pabpc4 is non-essential for development, but has roles in growth, post-natal survival and haematopoiesis

2025-11-23

Abstract excerpt

Cytoplasmic poly(A)-binding proteins (PABPCs) are multifunctional RNA-binding proteins which play crucial roles in mRNA translation and stability. In mammals, two family members, PABPC1 and PABPC4 appear widely expressed, but the consequences of their loss of function in vivo remain unknown, despite PABPC4 being implicated in a variety of human diseases. We address this knowledge gap using a series of Pabpc4 kno...

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Literature Corpus work: 01e6e61f-5dba-52d0-b866-98b10569759a
DOI: 10.1101/2025.11.22.689676

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