Article

Comparative analysis and directed protein evolution yield an improved degron technology with minimal basal degradation, rapid inducible depletion, and faster recovery of target proteins.

2024-11-15

Abstract excerpt

<title>Abstract</title> Biological mechanisms are inherently dynamic, requiring precise and rapid gene manipulation for effective characterization. Traditional genetic perturbation tools such as siRNA and CRISPR knockout operate on timescales that render them unsuitable for exploring dynamic processes or studying essential genes, where chronic depletion can lead to cell death. Here, we compared four major indu...

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Literature Corpus work: fa219a7b-8d8b-5270-a5c4-4af4f287ae11
DOI: 10.21203/rs.3.rs-5348956/v1

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Comparative analysis and directed protein evolution yield an improved degron technology with minimal basal degradation, rapid inducible depletion, and faster recovery of target proteins.DOI 10.21203/rs.3.rs-5348956/v1Read

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