Article

Deciphering acquired resistance mechanisms to sustained auxin-inducible protein degradation in cells and mice

2025-09-23

Abstract excerpt

Targeted protein degradation is a favorable strategy for studying the immediate downstream effects of protein loss-of-function. An appealing platform among these technologies is the auxin-inducible degron (AID) system. Although this system has been applied extensively to cell and animal models, degradation resistance to long-term auxin treatment has not been studied. With the advent of the new AID2 system, cellula...

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Literature Corpus work: 444afbeb-8466-58f9-8c66-8aa26e186df6
DOI: 10.1101/2025.09.21.677607

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