Article

Distinct roles of IDR and CCD domains control PABPN1 aggregation and enable therapeutic rescue

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>PABPN1 is a multifunctional protein whose expression is tightly regulated to maintain cellular homeostasis. PABPN1 dysregulation contributes to both common acquired diseases, such as bladder cancer, and rare inherited disorders, including oculopharyngeal muscular dystrophy (OPMD). In OPMD, PABPN1 forms insoluble aggregates that reduces its functional levels, leading to genome-wide shift...

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Literature Corpus work: dbaee813-52dc-54d9-b016-241759a73bf1
DOI: 10.21203/rs.3.rs-9942737/v1

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