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Large-scale GWAS meta-analysis of serum antibody levels reveals distinct genetic architectures

2025-10-28

Abstract excerpt

Antibodies are the principal effector proteins of humoral immunity. Dysregulated antibody production is a feature of a number of heritable immune-mediated diseases, such as the antibody deficiencies and IgA nephropathy. To characterise the common-variant architecture of serum antibody levels in the general population, we conducted the largest GWAS meta-analyses to date of serum IgA, IgM, and IgG, attaining sample...

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Literature Corpus work
b3465af9-6107-5559-9d12-84d20589b9ba
DOI
10.1101/2025.10.25.25338738
Open publication

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Large-scale GWAS meta-analysis of serum antibody levels reveals distinct genetic architecturesDOI 10.1101/2025.10.25.25338738
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