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Article

Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.

Human genetics - 22 Jun 2026

Dang Xiao, Wang Frank Qingyun, Zhang Caicai, Su Huidong, Lei Yao, Yang Jing, Lau Yu Lung, Yang Wanling

Abstract excerpt

Selective immunoglobulin A deficiency (IgAD) is the most prevalent primary immunodeficiency and frequently coexists with autoimmune diseases (ADs), suggesting a shared genetic etiology. While genome-wide association studies (GWAS) have identified only a few risk loci for IgAD and hundreds for ADs, systematic cross-trait analyses are lacking, leaving the shared genetic architecture and underlying mechanisms poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42329450
DOI: 10.1007/s00439-026-02850-5
PMCID: PMC13287149

Genes

APOBR
CD28
RAD51B
SH2B3
STAT4
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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