Article
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Genome medicine - 27 Jul 2018
Scepanovic Petar, Alanio Cécile, Hammer Christian, Hodel Flavia, Bergstedt Jacob, Patin Etienne, Thorball Christian W, Chaturvedi Nimisha, Charbit Bruno, Abel Laurent, Quintana-Murci Lluis, Duffy Darragh, Albert Matthew L, Fellay Jacques
Abstract excerpt
BACKGROUND: Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii) seroconversion rates, and (iii) intensity of antigen-specific immune responses. Here, we evaluated the impact of intrinsic...
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