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Article

Population-scale immunoglobulin genetics resolves the human B-cell system

2026-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Immunoglobulins (Ig) mediate adaptive humoral immunity, yet the regulation of B-cell responses in vivo in humans remains inaccessible to direct experimentation. Here we use population-scale Ig genetics to resolve molecular regulation of the human B-cell system. Analysis of circulating IgA, IgG, IgM, and six composite Ig traits in 114,697 individuals identifies 504 genetic associations. Integrat...

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Literature Corpus work
a209abdd-0c8e-5478-9f9d-035d88411957
DOI
10.64898/2026.03.30.715216
Open publication

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Population-scale immunoglobulin genetics resolves the human B-cell systemDOI 10.64898/2026.03.30.715216
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