Article

BloodVariome: a high-resolution atlas of inherited genetic effects in human immune cells

2026-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies have linked thousands of sequence variants to immune-mediated diseases, yet their cellular mechanisms remain largely unresolved. Here we present BloodVariome, a high-resolution atlas of genetic effects across the human immune cell hierarchy. Combining deep immunophenotyping with automated pattern-recognition, we quantified 1,533 traits across 127 immune cell popul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db364350-42b8-5518-a98e-071ab03c519a
DOI: 10.64898/2026.03.30.715213

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BloodVariome: a high-resolution atlas of inherited genetic effects in human immune cellsDOI 10.64898/2026.03.30.715213Read

The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.Semantic proximity Read

Single-cell analysis of human diversity in circulating immune cellsSemantic proximity Read

Dissecting genetic determinants of variation in human immune responses.Semantic proximity Read

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.Semantic proximity Read

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read

Population-scale immunoglobulin genetics resolves the human B-cell systemSemantic proximity Read

Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune CellsSemantic proximity Read

Genetic variants regulating immune cell levels in health and disease.Semantic proximity Read

Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathologySemantic proximity Read

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.Semantic proximity Read

Systems-level longitudinal immune profiling reveals individualized immunotypes and genetic associationsSemantic proximity Read

Impact of rare and common genetic variation on cell type-specific gene expression in human bloodSemantic proximity Read