Article

Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

2021-11-20

Abstract excerpt

Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome and has a known role in susceptibility to mucosal pathogens, celiac disease, inflammatory bowel disease, and IgA nephropathy. We performed genetic analyses of serum IgA levels in 41,263 individuals of diverse ancestries. We observed unexpected variability in IgA levels across major ancestral populations, with African a...

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Literature Corpus work: 0ae935d6-dd07-5e1f-a1bd-c8f96a821d60
DOI: 10.1101/2021.11.19.21265524

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