Article
Sequence variants influencing the regulation of serum IgG subclass levels.
Nature communications - 14 Sept 2024
Olafsdottir Thorunn A, Thorleifsson Gudmar, Lopez de Lapuente Portilla Aitzkoa, Jonsson Stefan, Stefansdottir Lilja, Niroula Abhishek, Jonasdottir Aslaug, Eggertsson Hannes P, Halldorsson Gisli H, Thorlacius Gudny E, Arnthorsson Asgeir O, Bjornsdottir Unnur S, Asselbergs Folkert W, Bentlage Arthur E H, Eyjolfsson Gudmundur I, Gudmundsdottir Steinunn, Gunnarsdottir Kristbjorg, Halldorsson Bjarni V, Holm Hilma, Ludviksson Bjorn R, Melsted Pall, Norddahl Gudmundur L, Olafsson Isleifur, Saevarsdottir Saedis, Sigurdardottir Olof, Sigurdsson Asgeir, Temming Robin, Önundarson Pall T, Thorsteinsdottir Unnur, Vidarsson Gestur, Sulem Patrick, Gudbjartsson Daniel F, Jonsdottir Ingileif, Nilsson Björn, Stefansson Kari
Abstract excerpt
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci influencing IgG...
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