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Disruption of the insulin signaling pathway in <i>C. elegans</i> dramatically increases male longevity and enhances reproductive health late in life

2025-11-06

Abstract excerpt

Males and females are known to have dramatically different health and lifespan trajectories, but the underlying basis for these differences is only now being fully investigated 1 . In the Caenorhabditis elegans nematode model system, most aging studies have been conducted with hermaphrodites, and little is known about male-specific responses to pro-longevity mutations. Several previous studies have used the auxi...

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Literature Corpus work
b33090fc-ca90-5d5a-b3a1-2f6434471c2c
DOI
10.1101/2025.11.04.686639
Open publication

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Disruption of the insulin signaling pathway in <i>C. elegans</i> dramatically increases male longevity and enhances reproductive health late in lifeDOI 10.1101/2025.11.04.686639
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