Back to search

Article

Glucose enrichment accelerates <i>C. elegans</i> reproductive aging via non-autonomous DAF-2/insulin-like receptor signaling in somatic tissues

2025-07-08

Abstract excerpt

Detrimental effects of chronic high-sugar overconsumption can extend from molecular and cellular responses to systemic changes. Reproductive systems are particularly sensitive to diet and energetic state, yet the long-term reproductive consequences of overnutrition are poorly defined. Here, we used Caenorhabditis elegans to study the impacts of glucose excess on reproductive aging. Glucose supplementation shorten...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ea183ba6-652f-5071-b21e-3728da1705fd
DOI
10.1101/2025.07.04.663088
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Glucose enrichment accelerates <i>C. elegans</i> reproductive aging via non-autonomous DAF-2/insulin-like receptor signaling in somatic tissuesDOI 10.1101/2025.07.04.663088
Disruption of the insulin signaling pathway in <i>C. elegans</i> dramatically increases male longevity and enhances reproductive health late in lifeSemantic proximity
Fourfold lifespan extension in <i>C. elegans</i> daf-2 mutant malesSemantic proximity
End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies.Semantic proximity
Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity
Nutrient sensing pathways regulating adult reproductive diapause in <i>C. elegans</i>Semantic proximity
O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.Semantic proximity
Glucose increases the lifespan of post-reproductive <i>C. elegans</i> independently of FOXOSemantic proximity
Nutrient sensing pathways regulating adult reproductive diapause in C. elegansSemantic proximity
Caenorhabditis elegans as a Useful Model for Studying Aging Mutations.Semantic proximity
End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologiesSemantic proximity
High-glucose diets have sex-specific effects on aging in C. elegans: toxic to hermaphrodites but beneficial to malesSemantic proximity
Somatic aging pathways regulate reproductive plasticity in <i>Caenorhabditis elegans</i>Semantic proximity
Select a neighboring publication to make it the new centre.