Article

Fourfold lifespan extension in <i>C. elegans</i> daf-2 mutant males

2025-12-05

Abstract excerpt

Aging is a universal biological process driven by conserved genetic networks that balance somatic maintenance with growth and reproduction. The insulin/insulin-like growth factor I signaling pathway is a central architect of this balance, and inhibiting its activity has long been established as a primary mechanism to extend lifespan across diverse species. However, our understanding of this pathway’s limits has be...

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Literature Corpus work: b892f683-1a11-5d0d-9758-fa43c41fc6ef
DOI: 10.64898/2025.12.02.691904

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