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Article

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster

29 Feb 2016

Abstract excerpt

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS...

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PMID: 26698870
DOI: 10.5483/bmbrep.2016.49.2.261

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