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Article

End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies.

eLife - 10 Sept 2021

Venz Richard, Pekec Tina, Katic Iskra, Ciosk Rafal, Ewald Collin Yvès

Abstract excerpt

Preferably, lifespan-extending therapies should work when applied late in life without causing undesired pathologies. Reducing insulin/insulin-like growth factor (IGF)-1 signaling (IIS) increases lifespan across species, but the effects of reduced IIS interventions in extreme geriatric ages remains unknown. Using the nematode Caenorhabditis elegans, we engineered the conditional depletion of the...

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PMID: 34505574
DOI: 10.7554/eLife.71335
PMCID: PMC8492056

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