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Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling.

Gerontology - 1 Jan 2018

Ewald Collin Yvès, Castillo-Quan Jorge Iván, Blackwell T Keith

Abstract excerpt

The groundbreaking discovery that lower levels of insulin/IGF-1 signaling (IIS) can induce lifespan extension was reported 24 years ago in the nematode Caenorhabditis elegans. In this organism, mutations in the insulin/IGF-1 receptor gene daf-2 or other genes in this pathway can double lifespan. Subsequent work has revealed that reduced IIS (rIIS) extends lifespan across diverse species, possibly including...

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Identifiers

PMID: 28934747
DOI: 10.1159/000480504
PMCID: PMC5828946

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