Article

End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

2021-05-31

Abstract excerpt

Preferably, lifespan-extending therapies should work when applied late in life without causing undesired pathologies. However, identifying lifespan-extending interventions that are effective late in life and which avoid undesired secondary pathologies remains elusive. Reducing Insulin/IGF-1 signaling (IIS) increases lifespan across species, but the effects of reduced IIS interventions in extreme geriatric ages rem...

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Literature Corpus work: a10b4a8f-75f2-50ae-8624-0911a1ad5a4c
DOI: 10.1101/2021.05.31.446422

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