Article

DAF-2/insulin IGF-1 receptor regulates motility during ageing by integrating opposite signaling from muscle and neuronal tissues

2021-10-15

Abstract excerpt

<h4>SUMMARY</h4> During ageing, preservation of locomotion is generally considered an indicator of sustained good health, in elderlies and in animal models. In C. elegans , mutants of the insulin-IGF-1 receptor DAF-2/IIRc represent a paradigm of healthy ageing, as their increased lifespan is accompanied by a delay in age-related loss of motility. However, these animals are less mobile than wild-type animals in e...

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Literature Corpus work: 3ce65e4f-5c3d-53a8-88ae-87cdda4a4769
DOI: 10.1101/2021.10.15.464514

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