Article

Autism risk genes converge on <i>PBX1</i> to govern neural cell growth

2025-03-13

Abstract excerpt

The alteration of neural progenitor cell (NPC) proliferation underlies autism spectrum disorders (ASD). It remains unclear whether targeting convergent downstream targets among mutations from different genes and individuals can rescue this alteration. We identified PBX1 as a convergent target of three autism risk genes: CTNNB1 , PTEN , and DVL3 , using isogenic iPSC-derived 2D NPCs. Overexpression of the PBX1a...

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Literature Corpus work: b2df78ce-9e93-5746-b959-83a233b592ab
DOI: 10.1101/2025.03.12.642693

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