Article

GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2 <sup>-/-</sup> cerebral organoids

2024-04-23

Abstract excerpt

We developed a human cerebral organoid model derived from induced pluripotent stem cells (iPSCs) with targeted genome editing to abolish protein expression of the Contactin Associated Protein-like 2 ( CNTNAP2) autism spectrum disorder (ASD) risk gene, mimicking loss-of-function mutations seen in patients. CNTNAP2 -/- cerebral organoids displayed accelerated cell cycle, ventricular zone disorganisation and increa...

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Literature Corpus work: a1fbd33e-bd04-555e-8c0f-6d9fb65d39d4
DOI: 10.1101/2024.04.21.590378

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