Article

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation

2019-12-03

Abstract excerpt

The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates novel high-throughput functional genomics approaches to elucidate the mechanisms of these genes. Here, we have coupled multiplexed repression of neurodevelopmental disease-associated genes to single-cell transcriptional profiling in differentiating human neurons to rapidly assay...

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Literature Corpus work: a5fe0c99-1a17-5eb2-8862-c05cf2394e5b
DOI: 10.1101/862680

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