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Dysregulation of mTOR Signaling Mediates Common Neurite and Migration Defects in Both Idiopathic and 16p11.2 Deletion Autism Neural Precursor Cells

2022-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Autism spectrum disorder (ASD) is defined by common behavioral characteristics, raising the possibility of shared pathogenic mechanisms. Yet, vast clinical and etiological heterogeneity suggests personalized phenotypes. Surprisingly, our iPSC studies find that six individuals from two distinct ASD-subtypes, idiopathic and 16p11.2 deletion, have common reductions in neural precursor cell (NPC) ne...

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Literature Corpus work
a134b5cc-886c-5c65-b60f-ac664bedfeca
DOI
10.1101/2022.09.17.508382
Open publication

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