Article

Autism-specific PTEN p.I135L mutation and an autism genetic background combine to dysregulate cortical neurogenesis

2022-11-16

Abstract excerpt

<h4>SUMMARY</h4> Alterations in cortical neurogenesis are implicated in neurodevelopmental disorders including autism spectrum disorders (ASDs). The contribution of genetic backgrounds, in additional to ASD risk genes, on cortical neurogenesis remain understudied. Here, using isogenic induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) and cortical organoid models, we report that a heteroz...

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Literature Corpus work: 32d7a9de-3028-53e7-8b94-e2a8791cf5de
DOI: 10.1101/2022.11.15.516317

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