Article

WNT/β-catenin dependant alteration of cortical neurogenesis in a human stem cell model of SETBP1 disorder

2021-10-12

Abstract excerpt

Disruptions of SETBP1 (SET binding protein 1) on 18q12.3 by heterozygous gene deletion or loss-of-function variants cause SETBP1 disorder. Clinical features are frequently associated with moderate to severe intellectual disability, autistic traits and speech and motor delays. Despite SETBP1 association with neurodevelopmental disorders, little is known about its role in brain development. Using CRISPR/CAS9 genom...

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Literature Corpus work: 2ce6dcd3-050a-564f-8367-927501bd0cdf
DOI: 10.1101/2021.10.12.464034

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