Article

Developmental convergence and divergence in human stem cell models of autism spectrum disorder

2024-04-02

Abstract excerpt

Two decades of genetic studies in autism spectrum disorder (ASD) have identified over a hundred genes harboring rare risk mutations. Despite this substantial heterogeneity, transcriptomic and epigenetic analyses have identified convergent patterns of dysregulation across ASD post-mortem brain tissue. To identify shared and distinct mutational mechanisms, we assembled the largest hiPS cell patient cohort to date, c...

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Literature Corpus work: fe2e1a9e-6e3e-513a-8108-42bb213d77e8
DOI: 10.1101/2024.04.01.587492

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