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Article

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.

Genome research - 1 Sept 2020

Lalli Matthew A, Avey Denis, Dougherty Joseph D, Milbrandt Jeffrey, Mitra Robi D

Abstract excerpt

The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel high-throughput functional genomics approaches to elucidate the molecular mechanisms of these genes. Here, we have coupled multiplexed repression of neurodevelopmental disease-associated genes to single-cell transcriptional profiling in differentiating human...

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Identifiers

PMID: 32887689
DOI: 10.1101/gr.262295.120
PMCID: PMC7545139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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