Article

Neurodevelopmental disorders and cancer networks share pathways; but differ in mechanisms, signaling strength, and outcome

2023-04-16

Abstract excerpt

Neurodevelopmental disorders (NDDs) and cancer are connected, with immunity as their common factor. Their clinical presentations differ; however, individuals with NDDs are more likely to acquire cancer. Schizophrenia patients have ∼50% increased risk; autistic individuals also face an increased cancer likelihood. NDDs are associated with specific brain cell types at specific locations, emerging at certain developm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f680a605-38e8-527a-8f2f-04ab0b5211bc
DOI: 10.1101/2023.04.16.536718

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neurodevelopmental disorders and cancer networks share pathways; but differ in mechanisms, signaling strength, and outcomeDOI 10.1101/2023.04.16.536718Read

Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcomeSemantic proximity Read

Autism and Cancer Share Risk Genes, Pathways, and Drug Targets.Semantic proximity Read

Systematic Reconstruction of Autism Biology with Multi-Level Whole Exome AnalysisSemantic proximity Read

Convergence and divergence of genes informed by common and rare variants of autism spectrum disorders in tissue-specific pathways and gene networks.Semantic proximity Read

Integrated gene analyses of <i>de novo</i> mutations from 46,612 trios with autism and developmental disordersSemantic proximity Read

Systematic reconstruction of autism biology from massive genetic mutation profiles.Semantic proximity Read

Brain Transcriptome of Autism Spectrum Disorders and Tourette Syndrome Defines Common Targetable Inflammatory Pathways Involving Cytokines, Complement, and Kinase SignallingSemantic proximity Read

Convergence and Divergence of Common and Rare Variants of Autism Spectrum Disorders in Tissue-specific Pathways and Gene NetworksSemantic proximity Read

Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genesSemantic proximity Read

Connecting the dots: Overlaps between autism and cancer suggest possible common mechanisms regarding signaling pathways related to metabolic alterations.Semantic proximity Read

Molecular signatures from multi-omics of autism spectrum disorders and schizophrenia.Semantic proximity Read

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancerSemantic proximity Read