Article

Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development

2026-06-30

Abstract excerpt

Rupture of the fibrous cap is the primary cause of clinical complications from atherosclerosis. Smooth muscle cells (SMCs) are a major contributor to fibrous cap development and stability through de-differentiation to extracellular matrix-producing cells. We previously showed that the antioxidant enzyme cytoglobin (CYGB) is expressed in vascular SMCs and regulates SMC dependent vascular remodeling and gene express...

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Literature Corpus work: b21a4c98-43ea-5d8e-88d0-a22be2f5164c
DOI: 10.64898/2026.06.25.734607

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