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Article

Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs

4 Oct 2017

Abstract excerpt

Fibrous cap smooth muscle cells (SMCs) protect atherosclerotic lesions from rupturing and causing thrombosis, while other plaque SMCs may have detrimental roles in plaque development. To gain insight into recruitment of different plaque SMCs, we mapped their clonal architecture in aggregation chimeras of eGFP+Apoe-/- and Apoe-/- mouse embryos and in mice with a mosaic expression of fluorescent proteins in medial...

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PMID: 28978793
DOI: 10.1172/jci.insight.95890

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