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Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis

9 Aug 2023

Abstract excerpt

Identifying novel regulators of vascular smooth muscle cell function is necessary to further understand cardiovascular diseases. We previously identified cytoglobin, a hemoglobin homolog, with myogenic and cytoprotective roles in the vasculature. The specific mechanism of action of cytoglobin is unclear but does not seem to be related to oxygen transport or storage like hemoglobin. Herein, transcriptomic...

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PMID: 37573836
DOI: 10.1016/j.redox.2023.102838

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