Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smooth Muscle Cell-Derived Fibronectin Promotes an Atheroprotective Smooth Muscle Cell Phenotype Associated With Altered NO-cGMP Signaling.

Journal of the American Heart Association - 3 Jun 2025

Feil Susanne, Zaldivia Maria T K, Kiesel Jacek, Roessing Malte, Peter Andreas, Morales-Cano Daniel, Bentzon Jacob F, Lehners Moritz, Feil Robert

Abstract excerpt

BACKGROUND: Coronary artery disease due to atherosclerosis is the leading cause of death worldwide. Recent studies revealed an important role of smooth muscle cell (SMC) phenotypic switching in atherogenesis. How the extracellular matrix affects SMC phenotype in atherosclerotic lesions is not well understood. Fibronectin (Fn1) is an abundant component of the extracellular matrix in plaques and has been linked to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic GMP

Share to Fibronectins

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Nitric Oxide

Share to Plaque, Atherosclerotic

Source

Open in PubMed Open full text

Identifiers

PMID: 40439151
DOI: 10.1161/JAHA.124.040395
PMCID: PMC12229189

Genes

GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smooth Muscle Cell-Derived Fibronectin Promotes an Atheroprotective Smooth Muscle Cell Phenotype Associated With Altered NO-cGMP Signaling.PMID 40439151Read ↗

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic PlaquesSemantic proximity Read ↗

Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formationSemantic proximity Read ↗

Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis.Semantic proximity Read ↗

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaquesSemantic proximity Read ↗

Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis.Semantic proximity Read ↗

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment.Semantic proximity Read ↗

Mouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populationsSemantic proximity Read ↗

BEYOND CONTRACTILITY: PHENOTYPIC SWITCHING OF VASCULAR SMOOTH MUSCLE CELLS IN ATHEROSCLEROSIS.Semantic proximity Read ↗

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesionsSemantic proximity Read ↗

Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap DevelopmentSemantic proximity Read ↗

Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCsSemantic proximity Read ↗

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.