Article
Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion Composition-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2026
Deaton Rebecca A, Raihan Tajbir, Milosek Victoria M, Allaham Fatema, Krinsky Alexandra L, Shankman Laura S, Como Alexander M, Alencar Gabriel F, Salamon Anita, Moradinasab Nazanin, Banerjee Subhashis, Owens Gary K
Abstract excerpt
BACKGROUND: Phenotypic plasticity of smooth muscle cells (SMCs) and endothelial cells (ECs) contributes to atherosclerotic plaque composition and stability, yet how shifts in one population influence the contribution and function of the other under conditions of vascular stress, such as irradiation, is poorly understood. A major limitation has been the inability to simultaneously fate-map both cell types within...
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