Article

Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure

2026-01-07

Abstract excerpt

Hypertension-mediated left ventricular hypertrophy and cardiac fibrosis often precede heart failure. Recent studies indicate that cytoglobin (Cygb), a globin expressed in the vasculature, increases systemic blood pressure. The present work aims to determine the role of Cygb in angiotensin II (Ang II)-induced cardiac hypertrophy and fibrosis in the mouse. <h4>Methods</h4> Males and females global Cygb knockout (C...

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Literature Corpus work: 9b901bdc-a949-5682-a66f-5f4c99e19576
DOI: 10.64898/2026.01.06.697990

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