Article

Colchicine promotes atherosclerotic plaque stability independently of inflammation

2023-10-03

Abstract excerpt

Atherosclerosis is a chronic inflammatory disease which is driven in part by the aberrant trans -differentiation of vascular smooth muscle cells (SMCs). No therapeutic drug has been shown to reverse detrimental SMC-derived cell phenotypes into protective phenotypes, a hypothesized enabler of plaque regression and improved patient outcome. Herein, we describe a novel function of colchicine in the beneficial modula...

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Literature Corpus work: 0b28819f-358c-5be5-90ee-d545ad3bb2f2
DOI: 10.1101/2023.10.03.560632

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