Back to search

Article

The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions

2020-05-21

Abstract excerpt

A hallmark of subclinical atherosclerosis is the accumulation of vascular smooth muscle cell (SMC)-like cells leading to intimal thickening. While medial SMCs contribute, the participation of hedgehog responsive resident vascular stem cells (vSCs) to lesion formation remains unclear. Using transgenic eGFP mice and genetic lineage tracing of S100β vSCs in vivo , we identified S100β/Sca1 cells derived from a S100β...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e4480655-8da2-5654-b92d-bb2826ae4e52
DOI
10.1101/2020.05.20.105981
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesionsDOI 10.1101/2020.05.20.105981
Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesionsSemantic proximity
Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.Semantic proximity
Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.Semantic proximity
Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formationSemantic proximity
Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion CompositionSemantic proximity
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases.Semantic proximity
Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular diseaseSemantic proximity
Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4Semantic proximity
Redistribution of the chromatin remodeler Brg1 directs smooth muscle–derived adventitial progenitor–to–myofibroblast differentiation and vascular fibrosisSemantic proximity
<i>Smad3</i> Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity
Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity
Smooth muscle stem cellsSemantic proximity
Select a neighboring publication to make it the new centre.