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Lack of evidence for interactions between APOE and Klotho genotypes on cognitive, dementia and brain imaging metrics in UK Biobank

2021-01-15

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<h4>Importance</h4> Recent research has suggested that genetic variation in the Klotho (KL) locus may modify the association between apolipoprotein e ( APOE ) e4 genotype and cognitive impairment. <h4>Objective</h4> Large-scale testing for associations and interactions between KL and APOE genotypes vs. risk of dementia (n=1,570 cases), cognitive abilities (n=174,513) and brain structure (n = 13,158) in older (60+...

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Literature Corpus work: b1dfc6d4-4c8d-5373-848d-b2203ae5fc93
DOI: 10.1101/2021.01.11.20248318

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Lack of evidence for interactions between APOE and Klotho genotypes on cognitive, dementia and brain imaging metrics in UK BiobankDOI 10.1101/2021.01.11.20248318Read

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Lack of evidence for interactions between <i>APOE</i> and <i>Klotho</i> genotypes on cognitive, dementia and brain imaging metrics in UK Biobank

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