Article

Impact of<i>APOE</i>,<i>Klotho</i>and sex on cognitive decline with aging

2024-07-21

Abstract excerpt

The effects of APOE and Klotho genes, both implicated in aging, on human cognition as a function of sex and age are yet to be definitively established. Here we showed in the largest cohort studied to date ( N = 320,861) that APOE homozygous ε4 carriers had a greater decline in cognition with aging compared to ε3 carriers (ε4/ε3 & ε3/ε3) as well as smaller hippocampi and amygdala ( N = 37,976). Critically, sex and...

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Literature Corpus work: 47a0fdc6-17eb-50ba-ba54-167c5ebbf629
DOI: 10.1101/2024.07.20.24310745

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